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Pragmatic trials are studies designed to provide information for the real-world practice of clinical. They are often characterized as a focus on the practical aspects of designing a study which include recruitment and consent, adherence and the use routinely available equipment.

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Pragmatic Software, a software firm provides a variety of casino games on online gambling platforms. Its iGaming solutions are used by the top operators and land-based casinos. The company provides front-end site design tools, analysis tools and marketing, promotions, security payment systems, customer support and bug-reporting. The company also provides an environment that is safe and secure with high-quality graphics, games and security.

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A pragmatic study that involves different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity which is essential for a pragmatic trial to be reliable and reduce bias in results, is also necessary. However, too much heterogeneity can result in problems with the trial design.

Pragmatic Play Pragmatic Play, one of the major players in the live casino market, offers various classic table games such as Blackjack and Roulette. The live studios of the company in Romania and Malta provide customers with an authentic gambling experience, and a wide variety of betting options via virtual. The company also has created various interactive games to make online gambling fun. Some of these shows have live hosts, while others are hosted by famous personalities from the industry.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are usually requested by practitioners and policy makers to guide their decision-making. They also provide a useful method to determine the cause-effect relationship between an intervention and its outcomes. However, they should not, be used to replace explanation studies.

The pragmatism concept is controversial and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the validity of a clinical or physiological hypothesis as well as pragmatic trials, which inform policy and practice decisions. They also suggested a framework dubbed PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic study, including the recruitment, design, and delivery of the intervention, and follow-up.

There is a growing increase in the number pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials that are randomized (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming increasingly sensitized to the subject of pragmatics. It is important to keep in mind, however, that the majority were conducted in primary-care settings.